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Symbol
Name
ID

Atl1
atlastin GTPase 1
MGI:1921241

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Ankle clonus

Lower limb spasticity

Spastic paraplegia

Spastic gait

Frequent falls

Peripheral axonal neuropathy

Hypoplasia of the corpus callosum

Degeneration of the lateral corticospinal tracts

Bradykinesia

Babinski sign

Paraplegia

Dysarthria

Intellectual disability, mild

Hyperreflexia

Lower limb hyperreflexia

Gait disturbance

Tip-toe gait

Motor delay

Peripheral neuropathy

Distal sensory impairment of all modalities

Hyperesthesia

Paresthesia

Distal sensory impairment

Impaired vibratory sensation

Impaired vibration sensation in the lower limbs

Disease(s) Associated with ATL1

hereditary sensory neuropathy type 1D

hereditary spastic paraplegia 3A

Mouse Phenotypes		abnormal corticospinal tract morphology	abnormal myelin sheath morphology
Availability	Mouse Genotype	abnormal corticospinal tract morphology	abnormal myelin sheath morphology
	Atl1^tm1.1Cbla/Atl1^tm1.1Cbla
	Atl1^tm1.2Cbla/Atl1^tm1.2Cbla

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23